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IGF-1 promotes protein synthesis, enhances glucose uptake in skeletal muscle, stimulates lipolysis in adipose tissue, and plays crucial roles in tissue repair and regeneration

Inflammatory mediators can induce production of prostaglandin E 2 (PGE 2 ) and NO, which in turn have the capacity to promote maturation and increase transport of melanosomes, to upregulate the expression of the tyrosinase gene, and to increase the complexity of the network of melanocytic dendrites

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Moreover, treatment with mitochondria-targeted antioxidant MitoQ preserves mitochondrial quality control, alleviates tubular injury, and restores kidney function by reversing mitophagy deficiency through the Nrf2/PTEN-induced kinase 1 (PINK) signaling pathway in db/db mice (68)

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Dissecting Molecular Cross-Talk Between Nrf2 and NF-B Response Pathways