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Semaglutide targets GLP-1 receptors , which control appetite and blood sugar

Moreover, GLP-1 agonist such as liraglutide activates cAMP that consequently inhibits the AKT signal pathway in pancreatic cancer cells (Zhao et al., 2014a

More recently, a randomised controlled trial of lixisenatide in early Parkinson's disease (the LIXIPARK study) was published in the New England Journal of Medicine (2024)

Updated date: 2025-10-24

Overall, studies have shown that these medications have an established safety profile in T1D, with only a modest effect on HbA1c, but significant weight loss, and a reduction in TDI