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A study revealed that metformin treatment induced temporal alterations in the expression of specific genes ( BCL2L11 , CDH1 , and CDKN1A ) and proteins in EC cell lines, demonstrating its anti-tumor and anti-proliferative properties in individuals with EC and PCOS (Lange et al., 2021)
Finally, while the timing of observed changes aligns closely with the formulary update, this analysis does not establish causality, and other factors such as regional policies, supply dynamics, or provider preferences may have contributed
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