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There is published work on each component alone, generated in different decades by different fields with different standards of evidence, and none of those studies had the other two present
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Tzivian, L., Winkler, A., Dlugaj, M., Schikowski, T., Vossoughi, M., Fuks, K., Weinmayr, G., & Hoffmann, B
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The reasons are biological, not cosmetic
Current Medicinal Chemistry
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