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In animal studies, semaglutide was associated with an increased risk of thyroid tumours
broccoli, Brussels sprouts, kale, etc.) Supplemental polyphenols may include: resveratrol, EGCG, and luteolin
Blinded allocation, centralized measurement of renal endpoints, and high retention rates support confidence in directionality of effect, while limitations arise primarily from study duration, sample size, and surrogate endpoints (albuminuria, eGFR slope)
Administration of fibroblast growth factor-21 (FGF21) and analogues and antibodies that exhibit agonism of the fibroblast growth factor receptor 1 (FGFR1)Klotho beta (KLB) receptor complex can reduce body weight, liver fat, insulin resistance and blood glucose in animal models of obesity and diabetes, and initial clinical studies have encouraged further interest [77]
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