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Although GLP-1 signaling interacts with other metabolic systems, evidence in the supplied papers supports a primary role in reducing food intake and externally driven eating rather than a simple generalized increase in energy expenditure
In this type 2 diabetes trial, orforglipron, even at the lower dose, outperformed both doses of oral semaglutide in reducing A1C, Kenneth Custer , PhD, executive vice president and president of Lilly Cardiometabolic Health, said in a statement
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