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The results are promising, but many hurdles to clinical usage remain

Bottom line Retatrutide is a groundbreaking, next-generation "triple G" weight loss injection that mimics three gut hormones to suppress appetite and elevate metabolism, clearing a historic 2026 Phase 3 trial with a surgery-like 28.3% average weight loss

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Side effects may persist for several weeks during elimination, with blood glucose levels typically rising within one to two weeks of stopping

Some patients may experience nausea, vomiting, constipation, diarrhea, appetite suppression, or other symptoms that limit dose escalation

N Engl J Med (2017) 377:83948