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It is especially recommended for those who are overweight or obese and not at glycemic goals despite aggressive insulin therapy
Fixed-dose combinations could optimize outcomes, particularly for patients with advanced disease or those unresponsive to monotherapy
& Herlyn, M
High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]
Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 811 April 2024
Acknowledgments The authors research is supported by the Italian Ministry of Health - Ricerca Corrente - IRCCS MultiMedica
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