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Cochrane Handbook for Systematic Reviews of Interventions version 6.4 [Internet]
Wan, S., Browning, K
The FDA recommends considering non-oral contraceptive methods or using backup contraception for 4 weeks after tirzepatide initiation and after each dose increase
However, the absence of hepatic decompensation or overt hepatotoxicity in the ESSENCE trial is reassuring and supports the use of semaglutide in patients with F2-F3 fibrosis, with appropriate monitoring
Prioritising protein intake (at least 1.2-1.6g per kilogram of body weight) and regular strength training helps preserve muscle while losing fat
Review all medications with the prescriber, follow titration instructions carefully and never increase a dose early because weight loss has slowed
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