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However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])

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It is correspondingly less effective but more sustainable as an introduction, especially for people who are used to snacking their entire waking time

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It is available as a multi-dose, prefilled pen that delivers a once-weekly injection subcutaneously

So for some people, Ozempic may provide greater benefits than Mounjaro