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Causes of Diverticulitis in the Sigmoid Colon This condition can be caused by multiple factors, including: Genetics A low-fiber and higher red meat diet Smoking Lack of exercise Age (diverticulitis is more common after age 50) Other risk factors for diverticulitis include: Obesity Heavy alcohol consumption Low vitamin D levels Medications such as steroids, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen (Advil, Motrin IB, others), and naproxen sodium (Aleve)
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