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doi:10.1159/000438465

Adjustments to the dosage may be required based on the subjects responses and study objectives

[8] With advancing age, there is a decline in proteasome activity in cardiac tissue, which represents a significant mechanism contributing to the increased susceptibility of older organisms to cardiovascular diseases

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Two patients gave themselves ten times the dose they should have, and all three of the patients had notable symptoms of nausea, vomiting, and abdominal pain for days