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The extra few percentage points at the very top come with the highest discontinuation rate, so it is a genuinely personal trade-off rather than an obvious upgrade
What constitutes unresponsive: Clinically, per manufacture, a patient should not be considered as unresponsive to therapy until less than 5% weight loss over the course of 3 months of GLP1/GIP medication at prescribed dose has been established
[21] When treated with cyanocobalamin, patients with Leber's disease may develop serious optic atrophy, possibly leading to blindness, based on few case reports
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