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The most frequently reported AHP symptoms upon ELEVATE enrollment were pain (47.6% [40/84]), nausea (31.0% [26/84]), fatigue (29.8% [25/84]), tingling, numbness, weakness or paralysis (26.2% [22/84]), and anxiety (23.8% [20/84])

Endogenous GLP-1 released from the gut acts directly on vagal afferents, which relay information from the abdomen to the brain and regulate multiple physiological systems

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Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota