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Compared to MK-677 (Ibutamoren, non-peptide oral secretagogue), Ipamorelin presents a more physiological pulsatile kinetics (peak-return-peak) versus MK-677 which produces a sustained non-pulsatile elevation that may desensitize the receptor long-term

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doi: 10.3390/ijms20061504 153 BarreraGPizzimentiSDagaMDianzaniCArcaroACetrangoloGPet al

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The compound has been found to operate in the postrema and nucleus of the hindbrain solitary tract in order to both induce satiety and regulate appetite by acting on receptors found in the laterodorsal tegmental nucleus, ventral tegmental area, and the hypothalamus [1]