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Most protocols use morning dosing, partly because of the cognitive enhancement intent (effects during waking hours) and partly because some users report mild stimulant-like effects that interfere with sleep if dosed too late

Type 2 Diabetes With Obesity# Recommendation : CagriSema Reason : REDEFINE 2 showed 13.7% weight loss with 73.5% of T2D patients achieving HbA1c of 6.5% or less, exceeding semaglutide's glycemic and weight results in T2D trials

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Consider adding microneedling to enhance absorption or switching to injectable delivery

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Wilson WR, Hay MP