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A missense mutation in the -synuclein gene (A53T) causes early-onset familial Parkinson's disease in the Contursi kindred
Benefits: Non-invasive and potential for CNS-targeted delivery
May 1 2023;18(5):602-612
The considerable recovery of the dopaminergic neuronal clusters in the park flies ensued better negative geotactic behavior in the flies and prolonged their life span, suggesting improvement in motor coordination dysfunction associated with PD
(3) studies that did not include a control group
