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This route expanded after the April 2026 reclassification opened the injectable pathway

Rytary is not recommended for people who are being treated with a nonselective monoamine oxidase (MAO) inhibitor an antidepressant medication or who have taken a MAO inhibitor within two weeks, as joining the two medications can lead to high blood pressure

Liraglutide (Saxenda) , a less powerful older GLP-1 drug, works well for appetite suppression, says Rao

liver and muscle lipid accumulation

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And its why medical guidance emphasises using these drugs alongside lifestyle changes: proper nutrition, strength training, and building sustainable eating patterns