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Variability in pharmacokinetic profiles among individuals, may influence clinical efficacy and safety, particularly when Ginkgo biloba is taken concomitantly with other medications (74)

Oxidative stress can impair aquaporin function, reducing the efficiency of cellular water uptake and retention

This underscores the potential value of structure-based design and rational modification of natural products for targeting necroptosis, warranting further exploration in this emerging area

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