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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

Toxicol Appl Pharmacol (2007) 225(2):198205

Short-term studies of CJC-1295 with DAC reported no serious adverse reactions, but the data are limited

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1997;56:5-21 Vasiliu I, Ciobanu-Apostol DG, Armasu I, Bredetean O, Serban IL, Preda C