doi: 10.1017/S0007114518003677
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Activation of this circuit in obese mice reduces food intake and improves glucose tolerance by stimulating insulin secretion via inhibition of GABA-input-dependent sympathetic nervous activity in the paraventricular hypothalamus
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Metformin can improve insulin sensitivity
Hormones, metabolism, insulin resistance, lifestyle habits, stress, sleep, and overall health all play a role in achieving sustainable results