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In line with this vital role in mitochondrial defense, Gpx4 null mice die during early embryonic development, while Gpx4 + / - cells are sensitive to oxidative stress triggers (Legault et al., 2000

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Both the FDA and the Food and Agriculture Organization of the United Nations (FAO)/ World Health Organization (WHO) have concluded that the levels of glutamic acid and glutamate salts typically consumed pose no risk to public health or safety , and neither organization has set an upper limit for glutamate intake

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