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Side effects - primarily gastrointestinal (nausea, vomiting, constipation, and abdominal discomfort) - are well-documented in clinical trial populations and are typically most pronounced during the initial titration phase before the body adapts to rising drug concentrations, which is why the standard-of-care approach involves gradual dose escalation over several weeks or months rather than starting at full therapeutic dose
For older adults (55+): Lower starting doses of 100-200 mcg are often recommended, with gradual increases as tolerated
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Published online July 8, 2024
This receptor has been reported to be expressed by colonic GLP-1-secreting enteroendocrine cells and pancreatic -and -cells (100, 101), with some controversy regarding the presence in murine islets (339)
It's found in every cell, with particularly high concentrations in the liver, where it aids in detoxification processes
