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Of the 119/48 total intermolecular NOEs for p53 TAD2 -FOXO4-DRI/p53 TAD2 -FOXO4 FH complexes only 19/2 NOEs could be assigned unambiguously

These are complementary strategies that address weight through different biological pathways -- CagriSema through dual appetite suppression mechanisms, retatrutide through appetite suppression plus increased energy expenditure