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NICE CKS, March 2024 (UK access only) Shipton MJ, Thachil J
To determine kinetic parameters for GR activity of TGR, substrate concentrations varied from 7.5 to 100 M GSSG and from 10 to 100 M NADPH
In vitro and in vivo studies demonstrate an IGF-1 deficiency can deregulate lipid metabolism, increase the risk of cardiovascular disease, and compromise the metabolic profile of diabetic patients
animal studies typically use 1 to 300 mcg/kg ranges, and extrapolated human protocols in research settings commonly cite 100 to 300 mcg per injection, though these are not FDA-approved doses
doi: 10.1016/j.metabol.2020.154303
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