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The lower Se level in ESKD patients found in this study is probably responsible for DNA damage and may promote the development of cancer in such patients (Letavayova et al., 2006)

To generate an endogenous HMOX activity reporter or an HMOX2 activity reporter, HA or HA-tagged HMOX2, respectively, and IFP2.0-P2A-EGFP were constructed in an optimized pRK5 vector