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The shikimate pathway is absent in mammals
There are no useful placebo controlled trials in humans for either
Summary: Folate deficiency and poor methylation may increase cancer risk
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Intramuscular injection, by contrast, deposits peptide 1540mm deep (depending on needle length and injection site), requiring the compound to enter venous return, circulate systemically, and then diffuse back out of dermal capillaries to reach fibroblasts
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