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Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells [PMID: 20702313] Laboratory literature summary: Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells
How strong this effect was found to be varied from study to study
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Orforglipron also produced significant but somewhat lower weight loss than oral semaglutide
BPC-157 is not registered as a drug in the EU or USA (clinical development PL 14736 halted at phase II in 2014) and has been on the WADA Prohibited List since 2022 in category S0 (non-approved substances)
A significant benefit in reducing death from cardiovascular causes was only shown in the LEADER trial with liraglutide (HR 0.78
