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JAC Antimicrob
Here we report crystal structures of the human GLP-1R transmembrane domain in complex with two different negative allosteric modulators, PF-06372222 and NNC0640, at 2.7 and 3.0 resolution, respectively
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Concurrently, an increase in adiponectin, an anti-inflammatory adipokine, was observed, suggesting a reprogramming of adipocyte secretion toward a protective phenotype
Lin EH, Rutter CM, Katon W, Heckbert SR, Ciechanowski P, Oliver MM, et al
