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The native or two modified GLP-1 (mGLP-1) with Ala8Gly substitution or Ala8Gly, Lys26Gln, and Lys34Asp substitutions were genetically fused to the N-terminus of HSA-binding DARPin through a rigid helical linker (EAAAK) 3 to create the fusion proteins, denoted as nGLP1-DARPin, mGLP1-DARPin-1, and mGLP1-DARPin-2, respectively
[Abstract]2022 Apr;38(4):386-402
Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity
Limited human observations corroborate a favorable short-term tolerability profile, usually involving mild, transient reactions such as localized injection-site irritation or temporary gastrointestinal discomfort
Both enzymatic and non-enzymatic antioxidant systems scavenge and deactivate excessive free radicals, helping to prevent cell damage
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