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The short answer: most of the ones people ask about

Hydroxychloroquine can inhibit iNOS levels in macrophages (109), downregulate M1 markers, and upregulate certain M2 markers, thereby promoting the transition of macrophages from the M1 to the M2 phenotype (110, 111)

Side effects determine whether people actually stay on the medication long enough to see those numbers become reality

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Acknowledgements This project received support from the Medical Research Council (MRC), UK, through an MRC Career Development Award to HP (Grant no: MR/T030968/1) and a UCL TRO Award (Grant no: MRC IAA 2021 UCL MR/X502984/1) at University College London, UK

doi: 10.1158/1541-7786.Mcr-17-0026 2 JitschinRHofmannADBrunsHGiesslABricksJBergerJet al