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The results showed that in high risk patients with T2D liraglutide reduced the risk of MACE by 13% (primary endpoint included cardiovascular death, non-fatal myocardial infarction (MI), and non-fatal stroke) ( In the ELIXA and the EXSCEL trials, GLP-1RAs (once daily lixisenatide and once weekly exenatide, respectively) didnt provide benefit in MACE reduction compared to placebo, but were non-inferior to placebo for the primary composite outcome of MACE

However, side effects of GLP-1 RAs, particularly those affecting the gastrointestinal system, may limit their use in patients with IBD

FrigeniMBalakrishnanBYinXCalderonFROMaoRPasqualiMet al

Res I, Mihalek I, Lichtarge O: An evolution based classifier for prediction of protein interfaces without using protein structures

Katz BJ et al