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This effect of BBR on lipid synthesis is mediated by the mitogen-activated protein kinase (MAPK/ERK) pathway, and can also be owing to the decrease in proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA

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as a consequence of increased FAO, tumor-infiltrating DCs differentiate toward a tolerogenic phenotype (tolDCs), with low antigen-presenting capacity and poor T cell priming ( We pause here to acknowledge the unique and important context of the TME, where multiple and often simultaneous challenges and changes impact the subsequent ability of immune cells to elicit potent anti-tumor responses

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doi: 10.1146/annurev.immunol.24.021605.090720 36 RavinKALoyM

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