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Histological examination Histological analysis of the skin was performed by taking 6 mm diameter biopsy punches from areas of interest

Overall, we found that during the early stages of reprogramming, cells undergo a depletion of H3K36me3 along gene bodies that compromises transcriptional fidelity, as reflected by a global increase in CT from expressed genes

The temptation to escalate the dose because nothing is happening yet is exactly the mistake the timeline section is designed to head off the mechanism is cumulative, not dose-chased

Adjust dose, wait 1-2 weeks to assess, then consider other changes if needed

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To increase these treatments effectiveness and get the desired results, you must be willing to make certain lifestyle changes