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Carey Goldberg, a contributing writer for Globe Ideas, is a former Boston bureau chief for The New York Times and Bloomberg News, and a former health and science reporter for the Globe and WBUR

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However, the authors note that substantial weight loss can be accompanied by reductions in lean body mass, underscoring the need for further research into dosing strategies and interventions that preserve muscle while promoting fat loss

Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Fig