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Pharmacokinetic comparisons between diabetic individuals and healthy individuals have shown that tirzepatide delays gastric emptying, particularly after a single dose, and demonstrates a decrease in effectiveness or responsiveness with repeated once-weekly dosing, referred to as tachyphylaxis [44, 72]

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Short-chain fatty acids (SCFA) in infants plasma and corresponding mothers milk and plasma in relation to subsequent sensitisation and atopic disease

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Furthermore, MT-II treatment in normal C57BL/6J mice did not significantly affect exploratory behavior in the open field test or repetitive behaviors as measured by the marble burying test