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In the study by Neelakantan et al

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Matos IV, Castejon E, Meavilla S, OCallaghan M, Garcia-Villoria J, Lopez-Sala A, et al

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

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Macrophage Polarisation Imbalance Oxidative stress and elevated free fatty acids in T2DM drive macrophage polarisation strongly toward the pro-inflammatory M1 phenotype