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Published trials showed that the treatment with GLP1-RA reduced the risk of MACE and slowed the development of albuminuria in diabetic patients, demonstrating a direct cardio and reno-protective action of GLP1-RA, regardless the effect on glycemic control (60, 61)

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10.1006/bbrc.1993.1117

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Fatigue and joint pain reduce activity, and low mood can affect eating patterns