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This study confirmed that tirzepatide induces a great improvement in insulin sensitivity compared to semaglutide, as already observed with HOMA-IR

JAMA 323 , 16121614 (2020)

This may be due to the sex hormones oestrogen and progesterone, which can alter the guts sensitivity

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However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD