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Annu Rev Cancer Biol 3:3554 Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death
Pharmaceutical companies widely produce anti-aging products that have glutathione as its the main ingredient
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Research on their absorption and long-term clinical benefit is still evolving, and results may vary depending on the product and the condition being studied
In this work, we show that ROXY9 has weak GSH-dependent de-glutathionylation activity on glyceraldehyde-3-phosphate dehydrogenase (GAPDH), but no oxidase or reductase activities on other substrates like HED, Cys-SG, cumene hydroperoxide (CHP) or roGFP2
