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Laboratory factors such as macro-B12 (immunoglobulin-bound B12) can cause spurious elevation on some assays

Any persistent or severe reaction should be reported to a healthcare provider immediately

This represents a significant limitation in the evidence base, as large-scale human trials examining musculoskeletal applications have not been published

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Test Spot Requirement SC: Initial 2.5mg test dose, monitor for 30 minutes for any reactions before full dose

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