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The key point: capsules are easier, but injections may be more direct
In high-fat-diet rodent models, changes in body mass or adipose-tissue measurements may reflect the experimental metabolic endpoint being studied, but safety interpretation is stronger when paired with food intake, body composition, activity, general observations, serum chemistry, hematology, organ weights, and histopathology
Oral supplementation or consumption of fortified foods is usually sufficient and first-line
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