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Track your water intake if necessary

The practical result is that tirzepatide tends to produce stronger appetite suppression, greater fat loss relative to lean mass, and improved metabolic markers compared to semaglutide at their respective optimal doses

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8 It seems, reviewing the published literature and the LOVD (www.lovd.nl), and HGMD (www.hgmd.cf.ac.uk) databases, that clEDS is often caused by gene conversion events and this is the most common recurrent mechanism of pathogenicity

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If standard doses are not tolerated, clinically appropriate alternatives might include slower titration (still within SmPC guidelines), switching to a different GLP-1 receptor agonist, considering other medication classes, enhancing diet/lifestyle support, or specialist review