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Side Effects Compared Both share similar GI side effect profiles since they both activate GLP-1 receptors: Tirzepatide generally shows lower GI side effect rates in trials, possibly because GIP receptor activation provides a "smoother" signaling profile than pure GLP-1 agonism

Other GLP-1 receptor agonists (such as dulaglutide or liraglutide) have different pharmacokinetic profiles and may be better tolerated

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Being unregulated, the peptide vials one buys may be of questionable purity or dosage

The discussion is best framed as a potential increased risk related to dehydration and rapid weight loss, balanced against the likely long-term benefits of improved metabolic health

However, her new Ozempic-inspired pills are raising many questions, with "do they really work" leading the pack