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Normal biogenesis of mitochondria is triggered in response to changes in the ATP/ADP ratio and to activation of AMPK which in turn results in increased expression of PPAR co-activator 1 (PGC-1) and nuclear respiratory factor-1 (NRF1)

DAM and DAA would be important conceptual entities, and disease association can be extended to various cell types, including other immune cells, glia, and neurons

This includes aggressive radical resting, strict symptom tracking, and learning to pace your physical and cognitive exertion to avoid triggering the lactic acid buildup that leads to PEM crashes