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Clinical trials have shown that side effects, including fatigue, are most prominent during the first few weeks of therapy and often diminish as the body adapts to the drug

Los efectos secundarios ms comunes estn relacionados con el sistema gastrointestinal, como nuseas, vmitos, prdida de apetito y diarrea, segn la Clnica Cleveland

This is the most clinically significant concern, as sustained heart rate elevation can increase cardiovascular risk in predisposed individuals Elevated blood pressure modest increases in both systolic and diastolic blood pressure were noted Restlessness and anxiety related to increased norepinephrine and dopamine activity Constipation reported by approximately 1520% of participants Nausea less common than with GLP-1 medications, reported by approximately 10% The cardiovascular effects elevated heart rate and blood pressure are the primary safety concerns with tesofensine

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This is significantly less expensive than pharmaceutical-grade products, which can cost $1,000 to $1,500 per month without insurance

Hakeem, A