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Zecca, E., Zuppa, A

Metabolic pathway enrichment analysis revealed that CAR T cell products of LTR have significantly increased pools of TCA metabolites, nucleotide biosynthesis intermediates, sphingolipid metabolism, and intermediates in central energy metabolism, as well as significantly decreased nucleotide catabolic and tRNA metabolism intermediates, which is critical for T cell activation 10 , compared to those of STR (Fig

A separate analysis in Nature Medicine found that retatrutide produced significant reductions in liver fat content in participants with metabolic dysfunction-associated steatotic liver disease (MASLD), suggesting benefits beyond simple weight reduction

Both peptides demonstrate convergent effects on angiogenesis promotion and inflammatory modulation while maintaining distinct molecular targets and cellular mechanisms, suggesting potential synergistic therapeutic applications in regenerative medicine contexts

& Karplus, P