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This research was supported by the National Natural Science Foundation of China This study was supported by the National Natural Science Foundation of China (81802504), the Sichuan Science and Technology Program (2025YFHZ0123), Chengdu Science and Technology Program (2024-YF05-01315-SN), and a grant from Shenzhen Weixin (2024HX008) for YW

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There is no established evidence that continuous use is either necessary or safe over long horizons

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