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Adults must also experience at least three of the following six associated symptoms: Restlessness or feeling keyed up or on edge Being easily fatigued Difficulty concentrating or mind going blank Irritability Muscle tension Sleep disturbance, either trouble falling asleep, staying asleep, or restless and unsatisfying sleep Children and adolescents face a lower threshold: only one symptom from this list is required

doi: 10.1006/mpat.1993.1014 35 KojicE

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Outcomes differed between strains, reinforcing that findings were dependent on the selected genetic model

In chronic alcohol models, BPC-157 attenuated withdrawal seizures over 24 hours following abrupt cessation

The pineal gland produces melatonin, the hormone that regulates sleep-wake cycles