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Metabolic research has established a correlation between hyperuricemia and disruptions in the primary bile acid pathway or intestinal metabolism, suggested that targeting the gut microbiome could offer innovative therapeutic approaches for managing hyperuricemia and its associated complications

The enzyme activity was expressed as nmol NADPH oxidized/min/mg protein using 6.22 mm 1 cm 1 as the molar extinction coefficient

Delayed-release metformin was about half as bioavailable as immediate-release or extended-release metformin, but was about 40% more potent than extended-release metformin in reducing fasting plasma glucose

The blood samples were diluted 1:2 in phosphate-buffered saline (PBS), layered onto a separation solution (Biocoll 1.077 g/ml, Biochrom AG, Berlin, Germany), and centrifuged (800 x g, 20 min, 20C, Multifuge X3 F2, Thermo Fisher Scientific, Dreieich, Germany)

L., Marks-Nelson, E

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